Brazil switced to alcohol fuel for autos some years ago. If I recall correctly, each car had to carry a gallon or so tank of gasoline to start on, then they could switch over to alcohol. Alcohol will not vaporize well enough at lower temps, and "lower" temps are still quite high in Brazil. Once the intake is warmed, even a little, then the alcohol works fine. The fuel mileage penalty is not half of what you would get on gasoline, as stated above, but it is in the neighborhood of 20-35% less MPG ,depending on compression ratio. I believe alcohol will work on higher compression ratios, as it has a higher octane rating than all but the highest test gasolines. Special oils would have to be formulated to use alcohol in two strokes.