Depends on the frame, and depends on the wheel. If you go using another narrow chain stay having frame like the last one (the reason it failed) it could be an issue but is an easier one to fix than an off center or wobbly rag joint
I am not shy about spreading stays, I have gone as far as +40mm on steel frames without issue... but DO NOT confuse that as a recommendation; spreading +10-15 is no big deal as long as you get it relatively square to the center line.
If you used an older (or cheap) freewheel threaded disc ready hub than you could cut the offset width difference of most 5 or 6 speed gears, but the wheel would need to be retrued to match the new offset.
I build wheels, so this is all simple stuff to me... although it can be difficult to adequately explain