Well, I have 3in tires, my friend has beefy 4 inchers, no chain clearance problems with a jackshaft. Not sure if the hassle of offsetting the engine and all that is actually better than a shift kit, it's relatively simple and by far brings the riding experience to a great level.
Really the fat tire is meant to get you riding where you once couldn't because of traction, why stop there when you could add a full range of gears to make the bike basically unstoppable on any terrain?
Again, I can't really justify trying to rig up a direct drive to a fat tire in my mind, the parts needed to ensure safe operation may very well cost as much as a jackshaft, and so you'd be limiting yourself for the same price, and you'll probably make more work for yourself in the long run trying to keep it all aligned while dealing with an awkward sizzling hot motor a little too close to your left leg.