I had to look very closely and expand the pic to identify the spot you questioned.
The right thing to do is figure out why the misalignment happened....as Wrench suggested. The problem with that missing piece is the cases' machined surfaces will not touch each other where the gasket is missing even after the case bolts are tight. Sealer alone probably.....could...or will get blown out from that spot. Sealer may or may not hold but...., why take the chance?
When assembling engine cases it's a good idea to clean the machined surfaces well with something like acetone and be sure nothing touches those surfaces after cleaning except a new, clean gasket OR sealer like motoseal, Or both...depending on your preference.
I've heard of people coating the gasket and surfaces with engine oil because oil will get to it from inside. I prefer the method above. I rather have clean case surfaces and gasket.
The last thing you want to happen is go through all the necessary work of assembling an engine, mounting it, alignment, support cables, etc then running it only to find the bad gasket spot(s) leak. Then you have to break it all down and start over.