Ohh my....
I'll often do this on either left or right
I wouldn't brag about that dude, especially on a shifter build when you need to work the throttle and gear shifter at the same time.
We are talking about just using your thumb and that requires your entire hand to leave the handle bars!
Sure, we all did 'Look Mom! No Hands!' riding our bicycles but in real life it's your 2 handed grip using your thumbs on the handle bars that keeps you on the thing.
Can you even imagine riding a bicycle let alone a motorized one with no thumbs?
I guess it would be impossible if it had a thumb throttle which again is something I find as 'silly' as thumb shifters.
My views on handlebar controls are based on what is easiest and safest for the rider.
A half grip twist shifter on the left rules in my book regardless of what the bike originally had, period.
One other note for you diret drive builders with a multi-speed pedal side...
If you have front a derailleur pull the whole damn thing out!
All of it! Just put the chain on the front sprocket you use and get it's shifter and cable off the handlebars!
All just tips, take 'em or leave 'em, all I know is what works best for me and my customers.