Quickness, aka acceleration, lies in the hands of the shift kit and rear gears. Unsure about the 3-speed hub, but the standard derailleur, chain and 8-speed cassette CAN reliably handle the power of the 4.2 hp+ of a piped GP460 engine.
You could use your GP460 engine and install it center-frame mount, via Scooterguy mount. I ran my 460 like that, after moving it from a friction drive position.
You could also install it center-mount position with shift kit. It would be a custom install, maybe starting with a 4-stroke center mounting plate. The 460 could be centered, but it would need the 5:1 pocket bike gearbox for low gear ratio. With engine centered in the frame, the engine sprocket would be far outboard and not align with the engine chainring sprocket. Then, a jackshaft would need to be used to align the drive chain with the engine chainring.
I'm partial to Scooterguy center mount with shift kit. Using the rear cassette will REALLY take full advantage of the 460's high rpm/narrow powerband. Your bicycle will become a very powerful entry-level quasi-motorcycle. The hills that are problematic now will be manageable at a higher speed than before. Besides that, a Scooterguy mount will allow you to bolt on an SBP expansion pipe. It's not the optimum pipe for the 460, but it fits snugly along the frame.
If you want it easy, a 4-stroke or Happy Time kit would fit better. If you want power, you already know what the 460 is capable of.
Did you ever have any problems with your 460's clutch? My clutch issue was the main reason why I changed from GP460 to Tanaka 47R engine.