There is always what looks to be air in the fuel of lines any of these bikes I have built when they are just sitting still, it's only when you throttle up that you would observe it being full up.Good question. I've found with a near vertical empty fuel line and filter once the fuel is opened there is always air trapped in the filter.
One would think that it would be completely full with no air left at all, with the tank vented but still the air won't all leave. This shouldn't occur. That's why I put a gentle suction to it, and it seems to work to completely evacuate all the air.
Perhaps my tanks aren't as well vented as I think they are ?