Just what is required to go highway or at least secondary road speeds? First, the posted speed limits are just suggested minimums by most users so on a 50 mph road most are booking over 60, many going a lot faster than that.
Tires and wheels that are speed rated, a frame with geometry designed for higher speed, then comes the subject of brakes. Higher speeds need more braking force.
Sorry to be a buzz kill but to make a bicycle that can go those speeds is asking for it. That is what motorcycles are designed for.
You don't need a 1000 cc Ducati v4 that will book 180 mph, a decent 250 or 350 is good enough to go 65-70 mph once and a while depending on the gearing. Not the most pleasant ride but safe enough.