I am afraid there are no hard&fast rules,a great deal depends on the quality of the engine and the conditions under which it operates.I would certainly not run any engine at max output routinely unless I was in the racing business.Max output means WOT at high rpm.In my book high rpm is faster than 80% of the speed at which the engine develops max. power, anything above the max power speed I would deem to be excessive and definitely to be avoided.If you end op running above this speed at still at PART throttle your gearing is too low and needs to be changed (less reduction)
Engines vary widely in life expectancy,component quality , operating temp. and lubrication (or the lack of it) are key factors,in this regard the forced air cooled engines shine,high temp. results in oil breakdown and accelerated wear.Use of synthetic oil along with frequent oil changes are inexpensive ways to combat this.These are after all tiny HIGHLY stressed engines.Any Japanese engine I know of is well engineered and built with excellent quality control.The Japanese are extremely quality conscious and demanding as consumers.But any engine can be abused and routinely running it at close to max.power is just that.Most car engines run normally at less than 40% of max rpm or power output.That's why they last. As far as the type of engine is concerned,I think 2 strokes hold something of an edge,mainly because of their inherent design symplicity.Chinese engines are suspect, unless their provenance is well established.In my opinion the Chinese make crummy junk for the export market.I would derate any of them by 50% or more,(limit throttle opening), which of course nobody does.As far as your initial query is concerned ,If you are running at full throttle and 6000 rpm,reducing your gear ratio would reduce your rpm and speed some,depending on the torque characteristic of your engine of which I know nothing.But it does not fundamentaly change the situation,you are pushing the envelope as far as I'm concerned and I would limit my speed to 25 mph or lower, then it would take you close to 2 hrs,or else get a more capable (larger) engine.Good luck,it will be an interesting experiment.