A little birdy tells me that SickBikeparts are developing a GT LTS replica frame - simply perfect for motorized applications with a full suspension design.
Full suspension is the cat's meow. My bike #2 has it.
My 2 cents- FS with a 3 speed hub and a shift kit would be perfect.
I am using a Sturmey Archer hub as a jackshaft with about 6 hp going thru it- no problems. Using a hub would get away from derailer issues and let one use cruiser chain which is stronger.
I think the internal shifting rear hubs aren't strong enough to handle anything over 2 horsepower. I could be wrong but they are made solely for pedal power.
Even Nuvinci doesn't list their hub as having enough mechanical integrity to be used in a motorized bicycle application, and you would think that it would be stronger than a Sturmey Archer design.