i have done two so far, with no problems. mine are steel frame bikes, so i don't wory about the integrity, i have been running my first build for almost 4 months on some rough roads with no signs of trouble.i do inspect often though. besides i have a mig welder, so at least on my bike, if i lose the frame integrity, i can rapidly restore it. i don't think i would want to drill an alloy frame .