Overall running expense should still be less $. Have to figure most 2 strokers use high test gas as well as the expensive oil. Most 4 strokes run fine on 87 and have little tuning issues. The 20 or so CC difference is enough to have better mpg as well. 49cc will run 7 minutes on just the bowl gas and the valve off. The wide cranks aren't even that bad if you have it hooked up right alignment is key. With a mid 30's power plant you really don't need 7 pedal gears either way.
Thats debatable, as you could run 87 in a 2 stroke as well. The cheapest good 2 stroke oil i know of is the supertech tc-w3 marine oil, about 11$ a gallon.
If where comparing apples to apples. Its going to need to be 50cc to 50cc.
A 49cc CG tuned right and running 40:1, and a 4 stroke running good and tuned.
Differences in operation cost will be pretty much neck and neck.
As 4 stroke kits cost about 230$, cg are about 80$.
Is say 100+mpg for both seems possible in the right conditions, add the cost of gas and oil and your pretty much neck and neck again.
overall, its what you like to run.