I built an e-trike using the Schwinn Meridian as a base unit; inexpensive, but a total mistake. As for the wheels, you'll probably never find any upgrade unless custom built. The axle has a unique d-shape, no keys, and impossible to find any hub that will slide on the axle properly. I ended up drilling out the hub holes, buying new rims and drilled them larger, and relaced the wheels using 12 gauge spokes. That stopped the spokes from breaking, but I was still limited as I had to use the original hubs.
As for that crazy d-shaped axle, another disaster. It is only 15 mm diameter (5/8") and quite weak. Even though on the online reviews I noticed that several people complained about axle breakage I thought it wouldn't happen to me. It did, at 25 mph in front of traffic from both directions. Luckily I got out of that one without so much as a scratch, but I took the remnants home, disassembled the bike, and sold the metal for scrap. I have no desire to ride something that obviously wanted to kill me.
If you have the resources, it's best to use an industrial tricycle that is built to handle 5 or 6 hundred pounds. I am using the Worksman right now; it has 11 gauge spokes, a 7/8" axle, and a frame that can take it.